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Novel Concepts for Organic Syntheses Based on Interfaces and Molecular Machines

[ Vol. 9 , Issue. 4 ]


Shinsuke Ishihara, Yutaka Wakayama, Nobuya Hiroshiba, Jonathan P. Hill and Katsuhiko Ariga   Pages 428 - 438 ( 11 )


Without doubt, organic chemistry has made significant contributions in improving the qualities of our lives. However, there exists a demand for well-designed molecules of complex structures with additional requirements for low-cost and low-energy production of the materials, which stimulate us to consider innovative concepts in organic synthetic methods. In order to propose innovative methods for next-generation organic synthetic procedures, we present two strategies, (i) organic synthesis within two-dimensional molecular patterns and (ii) organic synthesis driven by molecular machines working at interfaces. For example, synthesis of stereo-regulated polymeric materials in two-dimensional molecular arrays, tip-induced chemical reactions at a solid surface, sequential reactions guided by polymer chains, DNA-nanorobots on two-dimensional DNA origami, ester hydrolysis based on modified behavior of protonated amines at an interface, and several other methods are introduced as pioneering and innovative concepts.


Interface, DNA Origami, Molecular Machine, Molecular Recognition, Molecular Pattern, Surface, DNA-nanorobots, optimization.


WPI Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.

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