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Novel Concepts for Organic Syntheses Based on Interfaces and Molecular Machines

[ Vol. 9 , Issue. 4 ]

Author(s):

Shinsuke Ishihara, Yutaka Wakayama, Nobuya Hiroshiba, Jonathan P. Hill and Katsuhiko Ariga   Pages 428 - 438 ( 11 )

Abstract:


Without doubt, organic chemistry has made significant contributions in improving the qualities of our lives. However, there exists a demand for well-designed molecules of complex structures with additional requirements for low-cost and low-energy production of the materials, which stimulate us to consider innovative concepts in organic synthetic methods. In order to propose innovative methods for next-generation organic synthetic procedures, we present two strategies, (i) organic synthesis within two-dimensional molecular patterns and (ii) organic synthesis driven by molecular machines working at interfaces. For example, synthesis of stereo-regulated polymeric materials in two-dimensional molecular arrays, tip-induced chemical reactions at a solid surface, sequential reactions guided by polymer chains, DNA-nanorobots on two-dimensional DNA origami, ester hydrolysis based on modified behavior of protonated amines at an interface, and several other methods are introduced as pioneering and innovative concepts.

Keywords:

Interface, DNA Origami, Molecular Machine, Molecular Recognition, Molecular Pattern, Surface, DNA-nanorobots, optimization.

Affiliation:

WPI Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.



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