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1-Formyl-9H-β-Carboline: A Useful Scaffold for Synthesizing Substituted- and Fused β-Carbolines

[ Vol. 9 , Issue. 4 ]

Author(s):

Virender Singh and Sanjay Batra   Pages 513 - 528 ( 16 )

Abstract:


β-Carboline represents the core unit of several alkaloids and bioactive agents. This review assimilates the reports pertaining to the synthesis and applications of 1-formyl-9H-β-carbolines for affording 1-substituted, C-1-N-9 and C-1-N-2 fused β-carbolines.

Keywords:

β-Carboline, annulated- β-carboline, canthine, canthin-6-one, Morita-Baylis-Hillman, Cycloaddition, alkaloidsm topoisomerase-II, Pictet-Spengler reaction, anticonvulsant.

Affiliation:

Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), PO Box 173, Lucknow 226001, India.



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