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Catalytic Synthesis of Optically Active β-Amino Acid Derivatives

[ Vol. 9 , Issue. 5 ]

Author(s):

Pinaki S. Bhadury, Song Yang and Bao-An Song   Pages 695 - 726 ( 32 )

Abstract:


In continuation to our earlier reviews on organocatalysis, a systematic approach for the synthesis of chiral β-amino acid derivatives in the presence of mainly organocatalysts and transition metal catalysts are described. Asymmetric Mannich reactions catalyzed by proline and bifunctional organocatalysts are explained, whereas metal catalysis based on hydrogenation, Mannich and conjugate additions are elaborated. The resulting β-amino carbonyl moieties are essential structural units of many natural products and are important chiral building blocks for the synthesis of nitrogen-containing bioactive molecules.

Keywords:

Bifunctional organocatalysts, chiral β-amino acids, conjugate addition, hydrogenation, mannich reaction, proline, transition metal catalysts, transition metal, β-peptides, natural products, pharmaceuticals

Affiliation:

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P.R. China.



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