Submit Manuscript  

Article Details


One-pot Synthesis and its Practical Application in Pharmaceutical Industry

[ Vol. 9 , Issue. 6 ]

Author(s):

Wenyi Zhao and Fen-Er Chen   Pages 873 - 897 ( 25 )

Abstract:


Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.

Keywords:

Cascade reaction, multicomponent reaction, one-pot synthesis, tandem reaction, telescoping.

Affiliation:

Jacobus Pharmaceutical Company, Princeton, New Jersey 08540, USA.



Read Full-Text article