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Synthesis of a Common Tetrasaccharide Repeating Unit of the O-antigen of Enteroinvasive Escherichia coli O143 and Shigella boydii Type 81

[ Vol. 10 , Issue. 1 ]

Author(s):

Abhishek Santra and Anup Kumar Misra   Pages 178 - 182 ( 5 )

Abstract:


A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.

Keywords:

Escherichia coli, Shigella boydii, O-antigen, tetrasaccharide, dysentery

Affiliation:

Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India.



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