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Copper-Catalyzed Synthesis of Isoquinolines by the Cyclocondensation of ortho- Alkynyl Aromatic Aldehydes or Ketones with Urea

[ Vol. 10 , Issue. 2 ]

Author(s):

Jia Ju and Ruimao Hua   Pages 328 - 332 ( 5 )

Abstract:


A simple and efficient synthesis of isoquinoline derivatives by the condensation of ortho-alkynyl aromatic aldehydes/ketones with urea in the presence of copper salts is developed.

Keywords:

o-Alkynyl aromatic aldehyde, o-Alkynyl aromatic ketone, cyclocondensation, isoquinoline derivative, urea

Affiliation:

Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.



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