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First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters

[ Vol. 10 , Issue. 3 ]


Ramon Rios, SimonaHybelbauerova, Ivana C sa rova and Jan Vesel y   Pages 467 - 471 ( 5 )


A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic α,β- unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.


Cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization.


Reader in Organic Chemistry, Office B30-4028, University of Southampton, Highfield Campus, SO17 1BJ Southampton, UK.

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