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First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters

[ Vol. 10 , Issue. 3 ]

Author(s):

Ramon Rios, SimonaHybelbauerova, Ivana C sa rova and Jan Vesel y   Pages 467 - 471 ( 5 )

Abstract:


A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic α,β- unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.

Keywords:

Cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization.

Affiliation:

Reader in Organic Chemistry, Office B30-4028, University of Southampton, Highfield Campus, SO17 1BJ Southampton, UK.



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