Irem Kulu, Asli Kopruceli, Gokce Goksu and Nuket Ocal Pages 481 - 485 ( 5 )
The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl( hetaryl), N-[((4-pyrimidin-2-yl)piperazin-1-yl)butyl]substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.
Antidepressant drugs, bicyclic imides, biological activity, C-C coupling, isoxazolines, palladium(II) acetate, arylpiperazine moiety.
Yildiz Technical University, Faculty of Sciences and Arts, Department of Chemistry, Davutpasa Campus, 34210, Esenler- Istanbul, Turkey.