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A Formal [3+3] Cyclocondensation Strategy for the Synthesis of Polysubstituted Phenols by Reaction of Alkynyl Ketones with 1,3-Dicarbonyl Compounds

[ Vol. 10 , Issue. 3 ]


Jie Li, Ruimao Hua and Tao Liu   Pages 486 - 491 ( 6 )


The cyclocondensation of alkynyl ketones with 1,3-dicarbonyl compounds in the presence of NaOH in DMF at 80 °C affording polysubstituted phenols with high atom-efficiency in moderate to good total yields is developed.


Alkynyl ketones, cyclocondensation, 1, 3-Dicarbonyl compounds, phenols.


Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.

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