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Metal-Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: An Entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones

[ Vol. 10 , Issue. 3 ]


Wen-Bing Qin, Qiong Chang, Hai-Qinq Luo, Yun-Hong Bao, Zheng-Wang Chen and Liang-Xian Liu   Pages 492 - 499 ( 8 )


A simple, convenient and highly efficient aerobic oxidative trimerization of indoles has been developed using TEMPO in air, and the corresponding 3-(1H-indol-3-yl)-3,3'-biindolin-2- one derivatives were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.


Indoles, TEMPO, Oxindole, Trimerization, All-carbon quaternary.


Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. China.

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