Wen-Bing Qin, Qiong Chang, Hai-Qinq Luo, Yun-Hong Bao, Zheng-Wang Chen and Liang-Xian Liu Pages 492 - 499 ( 8 )
A simple, convenient and highly efficient aerobic oxidative trimerization of indoles has been developed using TEMPO in air, and the corresponding 3-(1H-indol-3-yl)-3,3'-biindolin-2- one derivatives were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of indoles.
Indoles, TEMPO, Oxindole, Trimerization, All-carbon quaternary.
Department of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, Jiangxi 341000, P. R. China.