Giammarco Tenti, Mª Teresa Ramos and Jose Carlos Menendez Pages 645 - 654 ( 10 )
An efficient method for the synthesis of pyridines related to nicotinic acid and their fused derivatives is described. The overall process involves a sequence comprising a four-component reaction that creates the heterocyclic framework from very simple open-chain precursors and two elimination steps, that are performed without the need for purifying any intermediate.
Multicomponent reactions, elimination reactions, heterocyclic synthesis, pyridines, quinolines.
Departamento de Quimica Organica y Farmaceutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.