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A New Multicomponent Protocol for the Synthesis of Pyridines and Fused Pyridines via a Formal aza [3+3] cycloaddition

[ Vol. 10 , Issue. 4 ]

Author(s):

Giammarco Tenti, Mª Teresa Ramos and Jose Carlos Menendez   Pages 645 - 654 ( 10 )

Abstract:


An efficient method for the synthesis of pyridines related to nicotinic acid and their fused derivatives is described. The overall process involves a sequence comprising a four-component reaction that creates the heterocyclic framework from very simple open-chain precursors and two elimination steps, that are performed without the need for purifying any intermediate.

Keywords:

Multicomponent reactions, elimination reactions, heterocyclic synthesis, pyridines, quinolines.

Affiliation:

Departamento de Quimica Organica y Farmaceutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.



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