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Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives

[ Vol. 11 , Issue. 2 ]


Wang Liju and Keyume Ablajan   Pages 310 - 316 ( 7 )


Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.


Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.


Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, P.R. China.

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