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A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent

[ Vol. 11 , Issue. 4 ]

Author(s):

Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior and e Flavia M. da Silva   Pages 605 - 611 ( 7 )

Abstract:


We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.

Keywords:

Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.

Affiliation:

Sintese Orgânica Ambiental - IQ/UFRJ, caixa postal: 68.584, CEP 21941-972 - Rio de Janeiro, RJ, Brasil.

Graphical Abstract:



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