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Non-Cross-Linked Polystyrene Supported Cyclosulfamide as a New Chiral Auxiliary for Asymmetric Aldol Reactions

[ Vol. 12 , Issue. 1 ]


Taotao Lu, Cuifen Lu, Junqi Nie, Zuxing Chen and Guichun Yang   Pages 61 - 66 ( 6 )


The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.


Asymmetric aldol reactions, chiral auxiliary, cyclosulfamide, non-cross-linked polystyrene, supported.


School of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, 430062, P. R. China.

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