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Non-Cross-Linked Polystyrene Supported Cyclosulfamide as a New Chiral Auxiliary for Asymmetric Aldol Reactions

[ Vol. 12 , Issue. 1 ]

Author(s):

Taotao Lu, Cuifen Lu, Junqi Nie, Zuxing Chen and Guichun Yang   Pages 61 - 66 ( 6 )

Abstract:


The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.

Keywords:

Asymmetric aldol reactions, chiral auxiliary, cyclosulfamide, non-cross-linked polystyrene, supported.

Affiliation:

School of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, 430062, P. R. China.

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