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An Elevated Throughput Synthesis of Enureas Advanced by Microwave Irradiated Pd-Catalyzed C-N Coupling of Alkenyl Nonaflates

[ Vol. 12 , Issue. 1 ]


Jignesh P. Dalvadi, Poojan K. Patel and Kishor H. Chikhalia   Pages 80 - 87 ( 8 )


A novel and flexible synthetic approach to enureas is described. This convenient method has been developed for the Pd-catalyzed C-N coupling reaction of alkenyl nonaflates with a variety of ureas. A ferrocene based phosphine ligand, Joshiphos appeared noticeable as the most dynamic catalyst and K3PO4 in t-BuOH was established to be the most favorable base-solvent combination for the reaction. This catalyst system displayed amazing functional group tolerance and assigned quick synthesis of the entire series of enureas in excellent yields.


Alkenyl nonaflate, aryl urea, Buchwald-Hartwig reaction, enurea, microwave assisted synthesis, Palladium catalyzed C-N coupling, urea.


Department of Chemistry, School of Science, Gujarat University, Ahmedabad 380009, Gujarat, India.

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