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An Elevated Throughput Synthesis of Enureas Advanced by Microwave Irradiated Pd-Catalyzed C-N Coupling of Alkenyl Nonaflates

[ Vol. 12 , Issue. 1 ]

Author(s):

Jignesh P. Dalvadi, Poojan K. Patel and Kishor H. Chikhalia   Pages 80 - 87 ( 8 )

Abstract:


A novel and flexible synthetic approach to enureas is described. This convenient method has been developed for the Pd-catalyzed C-N coupling reaction of alkenyl nonaflates with a variety of ureas. A ferrocene based phosphine ligand, Joshiphos appeared noticeable as the most dynamic catalyst and K3PO4 in t-BuOH was established to be the most favorable base-solvent combination for the reaction. This catalyst system displayed amazing functional group tolerance and assigned quick synthesis of the entire series of enureas in excellent yields.

Keywords:

Alkenyl nonaflate, aryl urea, Buchwald-Hartwig reaction, enurea, microwave assisted synthesis, Palladium catalyzed C-N coupling, urea.

Affiliation:

Department of Chemistry, School of Science, Gujarat University, Ahmedabad 380009, Gujarat, India.

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