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Total Syntheses of the Pyrrolidine Alkaloid, Hygrine

[ Vol. 11 , Issue. 6 ]


Matyas Milen, Peter Abranyi-Balogh and Gyorgy Keglevich   Pages 889 - 901 ( 13 )


The pyrrolidine ring can be found in numerous natural products and in many pharmaceuticals. Hygrine, as an example of a pyrrolidine alkaloid, is the biosynthetic precursor of pharmacologically important tropane alkaloids. This review summarizes the synthetic routes toward racemic and enantiopure hygrine.


Asymmetric synthesis, hygrine, labeled synthesis, natural products, pyrrolidine alkaloids, total synthesis.


Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Hungary.

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