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Total Syntheses of the Pyrrolidine Alkaloid, Hygrine

[ Vol. 11 , Issue. 6 ]

Author(s):

Matyas Milen, Peter Abranyi-Balogh and Gyorgy Keglevich   Pages 889 - 901 ( 13 )

Abstract:


The pyrrolidine ring can be found in numerous natural products and in many pharmaceuticals. Hygrine, as an example of a pyrrolidine alkaloid, is the biosynthetic precursor of pharmacologically important tropane alkaloids. This review summarizes the synthetic routes toward racemic and enantiopure hygrine.

Keywords:

Asymmetric synthesis, hygrine, labeled synthesis, natural products, pyrrolidine alkaloids, total synthesis.

Affiliation:

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Hungary.

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