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Applications of Barton-McCombie Reaction in Total Syntheses

[ Vol. 11 , Issue. 6 ]


Majid M. Heravi, Atefe Bakhtiari and Zeinab Faghihi   Pages 787 - 823 ( 37 )


The Barton-McCombie reaction (B-M reaction) is deoxygenation of aliphatic alcohols via thioacylation followed by a radical cleavage. Variations of the reactions may utilize different thioacyl fragments and hydrogen sources. In this review article, however, we have focused on the applications of this reaction as a mild and functional group tolerant method in deoxygenation step in total syntheses of some well recognized natural products.


Barton-McCombie reaction, deoxygenation, free-radical reaction, hydroxyl group, natural product, tin hydrid, total syntheses, xanthate.


Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran.

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