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Expeditious Synthesis of bis-(α-hydroxyalkyl)phosphinic Acid Using N-O-bis (trimethylsilyl)acetamide (BSA)

[ Vol. 12 , Issue. 2 ]


Chelliah Selvam and Francine Acher   Pages 168 - 172 ( 5 )


Highly efficient, synthetic procedure for bis-(α-hydroxyalkyl)phosphinic acids is described using N-O-bis( trimethylsilyl)acetamide (BSA). Various substituted aldehydes undergo the addition of hypophosphorous acid in good to excellent yields. Operational simplicity, high yield and shorter reaction time are the key features associated with this protocol.


α-hydroxyphosphinic acid, Hypophosphorous acid, N-O-bis(trimethylsilyl)acetamide, Phosphinic acids, P-alkylation.


Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX- 77004, USA.

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