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Synthesis of new 6-Spiro (Testosteron-3′-yl)-Hexahydro-3-Thioxo-1, 2, 3-Triazin-5-Ones and Related Derivatives as Affecting Enzymatic Agents

[ Vol. 12 , Issue. 3 ]

Author(s):

Dina Abed Bakhotmah   Pages 372 - 375 ( 4 )

Abstract:


A new 6-spiro (testosterone-3′-yl)-hexahydro-3-thioxo-1,2,3-triazin-5-ones (4a and 4b) have been synthesized by the condensation of testosterone and17-methyltestosterone(1a and 1b respectively) with thiosemicabazide. The first analogous 5 were obtained by oxidation while the second analogous 6-spiro (testosterone-3′-yl)-3-(4′-fluorophenyl)amino-1,2,3-triazin-5-ones (6) obtained by reaction of 4 with 4-fluoroaniline. These new compounds shows good to moderate affects on the activity of cellobiase produced by Aspergillus nidulans fungi.

Keywords:

Aspergillus nidulans, cellobiase, enzymatic agents, synthesis, testosterone-3, triazin.

Affiliation:

Department of chemistry, faculty of Science, king abdul-aziz university, Jeddah, Saudi Arabia

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