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A Simple and Efficient Procedure for Knoevenagel Reaction Promoted by Imidazolium-Based Ionic Liquids

[ Vol. 13 , Issue. 1 ]

Author(s):

Xiaomei Hu, Conelius Ngwa and Qinguo Zheng   Pages 101 - 110 ( 10 )

Abstract:


Various room temperature ionic liquids (RTILs), notably, 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]¯ , have been used to promote the Knoevenagel condensation to afford substituted olefins. All reactions proceeded effectively in the absence of any other catalysts or co-solvents with good to excellent yields. This method is simple and applicable to reactions involving a wide range of aldehydes and ketones with methylene compounds. The ionic liquid can be recycled without noticeable reduction of its catalytic activity. A plausible reaction mechanism is proposed.

Keywords:

Carbonyl compounds, catalysis, ionic liquids, Knoevenagel condensation, olefins.

Affiliation:

Science College, Northeast Agricultural University, Harbin, China, 150030; School of Life and Health Sciences, Aston University, Aston Street, Birmingham, B4 7ET, United Kingdom.

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