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Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture

[ Vol. 12 , Issue. 4 ]

Author(s):

Yogesh Kumar Tailor, Sarita Khandelwal, Hemant Kumar Jain and Mahendra Kumar   Pages 484 - 491 ( 8 )

Abstract:


Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and environmentally benign reaction medium.

Keywords:

Deep eutectic solvent, HBD (Hydrogen bond donor), Ionic liquid, Tandem reaction, Privileged heterocyclic structure, Spiroquinazolinone.

Affiliation:

Department of Chemistry, University of Rajasthan, Jaipur, 302004, India.

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