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Natural Naphthoquinones with Great Importance in Medicinal Chemistry

[ Vol. 13 , Issue. 3 ]

Author(s):

Fernando de Carvalho da Silva and Vitor Francisco Ferreira   Pages 334 - 371 ( 38 )

Abstract:


This review involves the chemistry and biochemistry of lapachol, β -lapachone and lawsone, examples of bioactive natural products that still being under biological evaluation and stimulated several research groups to prepare derivatives and analogues and test them against several anticancer, trypanocidal, antinflammatory, tuberculostatic, and antimalarial targets, as well as other parasitology targets related to important infectious diseases.

Keywords:

β-lapachone, lapachol, lawsone, derivatives, biological activities, synthesis.

Affiliation:

Universidade Federal Fluminense, Instituto de Química, Campus do Valonguinho, 24020-150 Niterói, RJ, Brasil.



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