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Total Synthesis of Natural Dihydropyranones: A Contribution to the Structural Elucidation of Natural Products. Coibacins A and B, Cryptomoscatones D1, D2 and E3

[ Vol. 12 , Issue. 5 ]

Author(s):

Ronaldo Aloise Pilli, Luiz Fernando Toneto Novaes, Vânia Maria Teixeira Carneiro, Roberta Lopes Drekener and Carolina Martins Avila   Pages 523 - 529 ( 7 )

Abstract:


Cryptomoscatones D1 and D2, dihydropyranones isolated from C. mandiocanna, had their stereochemistry solved after total syntheses and comparison of spectroscopic data of natural and synthetic samples. Natural dihydropyranones coibacins A and B, metabolites isolated from marine cyanobacterium cf. Oscillatoria sp, which display antileishmanial activity and anti-inflammatory properties, were synthesized and had their absolute configuration determined. Our efforts towards the synthesis of cryptomoscatone E3, natural dihydropyranone with unknown absolute configuration, are also discussed.

Keywords:

Polyketides, Total Synthesis, Structural Elucidation, Coibacin, Cryptomoscatone.

Affiliation:

Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de Campinas - Unicamp, P.O. Box: 6154, Campinas, Brazil.

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