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Advances in the Enantioselective Metal-catalyzed N-H and O-H Insertion Reactions with Diazocarbonyl Compounds

[ Vol. 12 , Issue. 5 ]


Antonio C. B. Burtoloso, João V. Santiago, Barbara Bernardim and Alexánder G. Talero   Pages 650 - 659 ( 10 )


Insertion of diazocarbonyl-derived metallocarbenes into X-H bonds (X= H, C, Si, N, O, S, P, Se) has proven to be a very important method for the construction of C-X bonds in organic chemistry. This mini-review provides a brief historical background, mechanistic aspects and a summary of recent breakthroughs in the area of enantioselective metal-catalyzed N-H and O-H insertion reactions.


Asymmetric catalysis, carbenes, diazocarbonyls, enantioselective, insertion reactions, metal catalysis.


Instituto de Química de São Carlos, Universidade de São Paulo, CEP 13560-970, São Carlos, Brasil.

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