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Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles

[ Vol. 12 , Issue. 6 ]


Daniela H. Oliveira, Diego Alves, Raquel G. Jacob and Maurício C. D. F. Xavier   Pages 822 - 829 ( 8 )


We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.


Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.


LASOL - CCQFA - Universidade Federal de Pelotas - UFPel - P.O. Box 354 - 96010-900, Pelotas, RS, Brazil.

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