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Isoxazolidines as Biologically Active Compounds

[ Vol. 13 , Issue. 5 ]


M.A. Chiacchio, S.V. Giofrè, R. Romeo, G. Romeo and U. Chiacchio   Pages 726 - 749 ( 24 )


This review is focused on the synthesis of isoxazolidines as the core of biologically active compounds having anti-cancer, antiviral, antibacterial and anti-inflammatory properties. The isoxazolidine ring, as mimetic of ribose, has been principally synthesized with high regio-, stereo- and enantioselectivity, applying the methodology of 1,3-dipolar cycloaddition, involving nitrones and alkenes as dipoles and dipolarophiles, respectively. The easy accessibility of this ring by this approach, then, makes this heterocycle, particularly suitable for the synthesis of small molecules useful in the design of new and modified drugs.


Isoxazolidines, 1, 3-dipolar cycloaddition, nitrones, anti-proliferative agents, nucleoside analogues, antiviral agents, antibacterials.


Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, viale A. Doria 6, 95125 Catania, Italy., Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, via SS. Annunziata, 98168 Messina, Italy.

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