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Multicomponent Synthesis of Novel bis(2-amino-tetrahydro-4H-chromene-3- carbonitrile) Derivatives Linked to Arene or Heteroarene Cores

[ Vol. 13 , Issue. 4 ]


Amna M. Abdella, Ahmed H. M. Elwahy and Ismail A. Abdelhamid   Pages 601 - 610 ( 10 )


An efficient and convenient route for synthesis of novel bis 4H-chromene-3- carbonitrile derivatives is reported. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine. A stepwise approach for the synthesis of the target compounds was also investigated.


Bis-aldehydes, bis-arylidenemalononitriles, multicomponent reactions, Bis-4H-chromene-3-carbonitriles.


Chemistry Department, Faculty of Science, Cairo University, Giza-Egypt.

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