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Novel Palladium-Catalyzed Cascade Reaction of 2-Methylindoles with 2-Iodobenzyl Bromide Leading to Indole Fused Tricyclo[7,3,1,02,7]trideca-2(7),3,5-triene Ring System

[ Vol. 13 , Issue. 6 ]

Author(s):

Edgars Abele, Sergey Belyakov, Tatjana Beresneva, Lena Golomba and Ramona Abele   Pages 883 - 887 ( 5 )

Abstract:


Novel palladium-catalyzed cascade reaction of 2-methylindoles with 2- iodobenzyl bromide in the system Pd(OAc)2 / Xantphos / t-BuOK / toluene leading to indole- fused tricyclo[7,3,1,02,7] trideca-2(7),3,5-triene ring system was presented. Palladium catalyzed reaction of 2-methylindoles with 6-bromo-5-bromomethylbenzo[1,3] dioxole leads to 3,3-bis(6-bromobenzo[1,3]dioxol-5-ylmethyl)-2-methyl-3H-indoles.

Keywords:

Palladium catalysis, 2-methylindoles, potassium t-butoxide, 2-iodobenzyl bromide, tricyclo[7, 3, 1, 02, 7]trideca-2(7), 3, 5-trienes.

Affiliation:

Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, Latvia.

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