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New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines

[ Vol. 14 , Issue. 4 ]

Author(s):

Esmail Vessally, Akram Hosseinian, Ladan Edjlali, Ahmadreza Bekhradnia and Mehdi D. Esrafili   Pages 557 - 567 ( 11 )

Abstract:


The development of efficient routes to pyrazines and their ring fused analogues is an attractive area of research since these compounds are now widely recognized as important N-heterocycles for their potential use in medicinal and agricultural scientific fields. In this review, we describe the most representative and interesting methods for the synthesis of pyrazines from N-propargylamines. Mechanistic aspects of the reactions are considered and discussed in detail.

Keywords:

Pyrazines, ring fused pyrazines, N-propargylamines, 6-exo-dig cyclization, 1, 3-dipolar cycloaddition.

Affiliation:

Department of Chemistry, Payame Noor University, Tehran, Iran; Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Department of Chemistry, University of Maragheh, Maragheh

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