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Synthesis of Phosphonates via Michaelis-Arbuzov Reaction

[ Vol. 14 , Issue. 6 ]


Boppudi Hari Babu, Gandavaram Syam Prasad*, Chamarthi Naga Raju and Mandava Venkata Basaveswara Rao   Pages 883 - 903 ( 21 )


Background: Michaelis–Arbuzov reaction has played a key role for the synthesis of dialkyl or diaryl phosphonates by reacting various alkyl or aryl halides with trialkyl or triaryl phosphite. This reaction is very versatile in the formation of P-C bond from the reaction of aliphatic halides with phosphinites or phosphites to yield phosphonates, phosphinates, phosphine oxides. The Arbuzov reaction developed some methodologies, possible mechanistic pathways, selectivity, potential applications and biologically active various phosphonates.

Objective: The synthesis of phosphonates via Michaelis–Arbuzov reaction with many new and fascinating methodologies were developed and disclosed in the literature, and these are explored in this review.

Conclusion: This review has discussed past developments and vast potential applications of Arbuzov reaction in the synthesis of organophosphonates. As presented in this review, various synthetic methodologies were developed to prepare a large variety of phosphonates. Improvements in the reaction conditions of Lewis-acid mediated Arbuzov rearrangement as well as the development of MW-assisted Arbuzov rearrangement were discussed. Finally, to achieve high selectivities and yields, fine-tuning of reaction conditions including solvent type, temperature, and optimal reaction times to be considered.


Michaelis–Arbuzov reaction, Photo-Arbuzov rearrangement, trialkyl phosphite, phosphonates, phosphinates, phosphine oxides.


Division of Plastic Surgery, Department of Surgery, Montreal General Hospital, McGill University, Montreal, H3G 1A4, Department of Chemical Sciences, Sree Vidyanikethan Degree College, Sree Sainath Nagar, Tirupati 517102, Department of Chemistry, Sri Venkateswara University, Tirupati 517502, Department of Chemistry, Krishna University, Machilipatnam 521001

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