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Tin Powder-Mediated One-Pot Protocols for Allylation Reactions by Allylic Halides

[ Vol. 14 , Issue. 8 ]

Author(s):

Nibras Ahmed Elaas, Waggas Ahmed Elaas, Danfeng Huang, Yulai Hu* and Ke-Hu Wang   Pages 1156 - 1171 ( 16 )

Abstract:


Background: Tin-promoted allylation of carbonyl or imino groups is one of the most convenient and efficient methods for synthesis of homoallylic compounds, which are versatile building blocks in the preparation of many biologically active molecules and natural products.

Objective: This review provides an insight into one-pot allylation reactions for the synthesis of different homoallylic compounds promoted by tin powder.

Conclusion: In the last four decades, tin powder-promoted allylation process has been exploited in synthesis of homoallylic compounds. This multicomponent “one-pot” strategy avoids a lengthy separation process and purification of the intermediate chemical compounds, which saves time and resources while increasing the chemical yield. This tin-promoted process has the following features: operational simplicity, good tolerance to functional groups and improved yields. The protocol could be carried out under wet conditions or even in pure water.

Keywords:

Tin powder, One-Pot, allylation reaction, allylic bromide, homoallylic alcohol, homoallylic amines.

Affiliation:

College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070

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