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Strategies for the Synthesis of Hydroxamic Acids

Author(s):

Ankit Ganeshpurkar, Devendra Kumar and Sushil K. Singh   Pages 1 - 12 ( 12 )

Abstract:


Hydroxamic acids are major class of organic compounds having a wide variety of pharmacological actions in targeting cancers, cardiovascular diseases, HIV, Alzheimer’s disease, Malaria, Allergic diseases. They are conventionally synthesized via carboxylic acid and their acid chloride derivatives. However, some other functional groups i.e. aldehyde, amine, amide and alcohol can also be converted to hydroxamate with ease. The solid phase synthesis techniques are also becoming popular for the synthesis of hydroxamic acids and these pathways have opened a wide arena for the synthesis of diverse and complex hydroxamic acids. The present review focuses on the chemistry of conventional and non-conventional routes for the synthesis of hydroxamic acids reported till date.

Keywords:

Hydroxamic acid, aldehyde, carboxylic acid, amide, alcohol.

Affiliation:

Indian Institute of Technology (Banaras Hindu University) - Department of Pharmaceutics Varanasi, Uttar Pradesh, , Indian Institute of Technology (Banaras Hindu University) - Department of Pharmaceutics Varanasi, Uttar Pradesh, , Indian Institute of Technology (Banaras Hindu University) - Department of Pharmaceutics Varanasi, Uttar Pradesh



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