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Multicomponent Reactions in the Synthesis of Complex Fused Coumarin Derivatives

[ Vol. 15 , Issue. 1 ]

Author(s):

Ligia S. da Silveira Pinto, Mara R.C. Couri and Marcus V.N. de Souza*   Pages 21 - 37 ( 17 )

Abstract:


Background: Coumarin is an important class of natural products with applications in different areas of knowledge. Due to its importance, several methodologies and strategies have been developed for the synthesis of different classes of compounds containing this nucleus.

Objective: The aim of this review is to cover in the last five years the complex fused coumarin derivatives synthesized in one-pot three-component reactions.

Conclusion: Considering that multicomponent reactions are a powerful tool to produce simple and complex compounds in one or few steps with high selectivity and yields while following the green chemistry principles.

Keywords:

Coumarins, green chemistry, multicomponent reactions, natural products, synthesis, derivatives.

Affiliation:

Departamento de Quimica Organica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Departamento de Quimica Organica, Universidade Federal de Juiz de Fora, Juiz de Fora, Departamento de Quimica Organica, Universidade Federal do Rio de Janeiro, Rio de Janeiro

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