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The Discovery of Ultrasound Irradiation as a Useful Tool for Accelerating Petasis Three-component Reaction: Synthesis of α-arylglycines

Author(s):

Fan Yun, Chunhui Cheng, Jingxuan Li, Pingwah Tang* and Qipeng Yuan   Pages 1 - 11 ( 11 )

Abstract:


We discovered ultrasound irradiation as a useful and efficient tool for accelerating Petasis reaction to prepare arylglycines, important non-proteinogenic amino acids. Petasis 3-component reactions are very useful in or-ganic synthesis, but they are known to be very slow. Using ultrasound irradiation, we were able to shorten the reaction times from 5 to more than 20-fold. Petasis reaction accelerated by ultrasound has not been previously reported in the literature.

Keywords:

organic synthesis, arylglycines, Petasis reaction, Multi-component, ultrasound, acceleration.

Affiliation:

State Key Laboratory of Chemical Resource Engineering, Organic and Medicinal Chemistry Division, College of Life Science and Technology, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029, State Key Laboratory of Chemical Resource Engineering, Organic and Medicinal Chemistry Division, College of Life Science and Technology, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029, State Key Laboratory of Chemical Resource Engineering, Organic and Medicinal Chemistry Division, College of Life Science and Technology, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029, State Key Laboratory of Chemical Resource Engineering, Organic and Medicinal Chemistry Division, College of Life Science and Technology, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029, State Key Laboratory of Chemical Resource Engineering, Organic and Medicinal Chemistry Division, College of Life Science and Technology, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029



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