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An Overview on Chemistry and Biological Importance of Pyrrolidinone

Author(s):

Zahra Hosseinzadeh, Ali Ramazani*, Kamaleddin Hosseinzadeh, Nima Razzaghi-Asl and Farideh Gouranlou   Pages 1 - 13 ( 13 )

Abstract:


Background: Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compound for designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compound indicating notable pharmaceutical effects. Many procedures for the preparation of pyrrolidinone and also their various reactions offer great scope in the field of medicinal chemistry. This fascinating group of compounds has diverse pharmacological activities such as antibacterial, antifungal, anticancer and anticonvulsant.

Objective: The review article proposes to classify comprehensive information on chemistry and pharmaceutical effects of pyrrolidinone in order to open new viewpoint for future studies.

Conclusion: It is clear from the review of the topic that a wide spectrum of pyrrolidinone analogues have been synthesized and the majority of these derivatives have indicated different significant biological activities. Thus, these analogues can be used for future progression of novel drugs against many more poor agents.

Keywords:

Pyrrolidinone, Heterocyclic, Biological activities, Antimicrobial, Anticancer, Industrial applications

Affiliation:

Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Water and Wastewater Research Center, Applied Chemistry Department, Faculty of Chemistry, Razi University, Kermanshah, Water and Wastewater Research Center, Applied Chemistry Department, Faculty of Chemistry, Razi University, Kermanshah, Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, Tehran



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