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Emerging Role of Green Oxidant I2/DMSO in Organic Synthesis

[ Vol. 15 , Issue. 6 ]

Author(s):

Pedavenkatagari Narayana Reddy*, Basireddy V. Subba Reddy and Pannala Padmaja*   Pages 815 - 838 ( 24 )

Abstract:


Background: I2/DMSO oxidative system catalyzed reactions have received considerable attention because they represent the advantages of being greener, efficient, atom-economical, low-cost, with mild conditions and ecofriendliness that meet with the requirements of sustainable chemistry. In recent times, the I2/DMSO oxidative system has been successfully applied in different types of organic reactions.

Objective: The aim of this review is to highlight the synergistic effect of the combined use of iodine and DMSO in organic synthesis.

Conclusion: It is clear from the review of the topic that a vast amount of work has been done in this area, employing an I2/DMSO system for diverse types of oxidative transformations as well as C-C and C-X bond formation reactions. In these reactions, iodine acts as a mild Lewis acid catalyst and DMSO servers as an oxidant, solvent and oxygen source. The role of iodine, DMSO as well as key intermediates involved in these reactions is discussed.

Keywords:

Iodine, DMSO, Oxidative amidation, Oxidatve annulations, Oxidative cross-coupling, C-H Functionalization, Chalcogenylation, Sulfenylation, Multicomponent reactions.

Affiliation:

Department of Chemistry, School of Technology, Gitam University, Hyderabad 502 102, CSIR – Indian Institute of Chemical Technology, Hyderabad 500 007, Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad 500085

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