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1,4-Diazepines: A Review on Synthesis, Reactions and Biological Significance

[ Vol. 16 , Issue. 5 ]

Author(s):

Muhammad A. Rashid, Aisha Ashraf*, Sahibzada S. Rehman, Shaukat A. Shahid, Adeel Mahmood and Muhammad Faruq   Pages 709 - 729 ( 21 )

Abstract:


Background: 1,4-Diazepines are two nitrogen containing seven membered heterocyclic compounds and associated with a wide range of biological activities. Due to its medicinal importance, scientists are actively involved in the synthesis, reactions and biological evaluation of 1,4-diazepines since number of decades.

Objective: The primary purpose of this review is to discuss the synthetic schemes and reactivity of 1,4- diazepines. This article also describes biological aspects of 1,4-diazepine derivatives, that can be usefully exploited for the pharmaceutical sector.

Conclusion: This review summarizes the abundant literature on synthetic routes, chemical reactions and biological attributes of 1,4-diazepine derivatives. We concluded that 1,4-diazepines have significant importance due to their biological activities like antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal and anticancer. 1,4-diazepine derivatives with significant biological activities could be explored for potential use in the pharmaceutical industries.

Keywords:

1, 4-Diazepines, synthesis, reactions, biological activities, heterocyclic compounds, biological activities.

Affiliation:

Department of Chemistry, Government Postgraduate College of Science, Faisalabad, Department of Chemistry, Government College Women University, Faisalabad, Department of Chemistry, Government Postgraduate College of Science, Faisalabad, Department of Physics, Government Postgraduate College of Science, Faisalabad, Department of Environmental Sciences, Government College Women University, Sialkot, Department of Chemistry, Government Postgraduate College of Science, Faisalabad

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