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Advances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4- d]pyrimidines

[ Vol. 16 , Issue. 6 ]

Author(s):

Mohamed Monier, Doaa Abdel-Latif, Ahmed El-Mekabaty, Başak D. Mert and Khaled M. Elattar*   Pages 812 - 854 ( 43 )

Abstract:


The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of heterocyclic compounds incorporated the pyrido[3,4-d]pyrimidine scaffold as demonstrated by chemical reactions and different preparation processes. The anticipated compounds were synthesized from pyridine or pyrimidine compounds and a description of the reactivity of substituents attached to ring carbon and nitrogen atoms is discussed. On the other hand, the synthesis and reactions of fused heterocycles incorporated pyrido[3,4-d]pyrimidine scaffold is described. The diamine analogs included pyrido[3,4-d]pyrimidine core were reported as tyrosine kinase inhibitors. The chemical reactions of certain unexpected and chemically substantial compounds have been discussed.

Keywords:

Pyrido[3, 4-d]pyrimidines, substituents’ reactivity, synthetic routes, biological applications, heterocyclic compounds, tyrosine kinase inhibitors.

Affiliation:

Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Department of Energy Systems Engineering, Adana Alparslan Turkes Science and Technology University, Adana 01250, Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516

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