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A Brief Synthesis of 2,2’-arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1- one) Catalyzed by TEAOH in Various Solvents

Author(s):

Hui Gao , Xiaobi Yang, Xinyu Tang, Pengcheng Yin and Zewei Mao*   Pages 1 - 8 ( 8 )

Abstract:


A concise and practical method was developed for one-pot synthesis of 2,2’-arylmethylene bis(3- hydroxy-5,5-dimethyl-2-cyclohexene-1-one) derivatives by the Knoevenagel condensation/Michael addition tandem reactions of aromatic or heteroaromatic aldehydes and 5,5-dimethyl-1,3-cyclicdiketone catalyzed by tetraethylammonium hydroxide (TEAOH) at room temperature in various solvents. This strategy provides several advantages over the traditional synthetic method, such as mild condition, simple work-up procedure, good yields (up to 92%) and variable solvents.

Keywords:

Concise synthesis, TEAOH, cyclohexanedione, aromatic or heteroaromatic aldehyde

Affiliation:

College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, P. R. , College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, P. R. , College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, P. R. , College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, P. R. , College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, P. R.



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