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Synthetic Approaches Towards Antihypercholesterolemic Drug Simvastatin

[ Vol. 16 , Issue. 5 ]

Author(s):

Tanzeela A. Fattah*, Aamer Saeed* and Syeda A. Shehzadi   Pages 652 - 670 ( 19 )

Abstract:


Cardiovascular diseases are among the most threatening problems being faced by twenty-first century humans. The core cause of these diseases is high cholesterol level. Simvastatin (1: Synvinolin) is a well-known cholesterol-lowering drug marketed under the trade name ZocorĀ®, which significantly reduces the risk of cardiovascular diseases related to hypercholesterolemia and is effective in lowering the total plasma cholesterol, low-density and very low-density lipoprotein cholesterol. It also enhances the high-density lipoprotein cholesterol. This review article aims to provide an overview of several chemical and biological methods utilized for the production of simvastatin in high yields and purity. Many robust and scalable methods have been described using lovastatin (2: Mevinolin) as a starting material, produced by the fungal strain of Aspergelius terreus. Enzymatic synthesis of simvastatin is also highlighted in this review. In addition, detailed experimental conditions, as well as the compatibility for industrial-scale preparations of simvastatin are also discussed.

Keywords:

Simvastatin, cholesterol, lovastatin, chemical synthesis, biocatalytic synthesis, cardiovascular diseases.

Affiliation:

Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Sulaiman Bin Abdullah Aba Al-Khail-Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS), International Islamic University, Islamabad 44000

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