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Contemporary Progress in the Synthetic Strategies of Imidazole and its Biological Activities

[ Vol. 16 , Issue. 8 ]

Author(s):

Jay Soni, Ayushi Sethiya, Nusrat Sahiba, Dinesh K. Agarwal and Shikha Agarwal*   Pages 1078 - 1104 ( 27 )

Abstract:


Heterocyclic compounds are pervasive in many areas of life and one of the heterocycles, imidazole is a unique heterocyclic five-membered aromatic compound having two sp2 hybridized nitrogen atoms. Its integral name is 1, 3 diazole and previously, it was known as glyoxalin. This moiety has achieved a considerable place among scientists in recent years by reason of its divergent synthetic strategies and uncommon biological and pharmacological activities, for example, anti-convulsant, anti-microbial, anti-cancer, anti-inflammatory, anti-tumor, anti-viral, anti-ulcer, analgesic, etc. Due to distinct therapeutic actions, it is still an engrossed area of research. Researchers currently are inventing new greener methods to synthesize its derivatives and to improve its pharmacological activities. The purpose of this review is to study the literature that can help researchers to explore this area, its prevailing program for synthesis in environmentally friendly conditions and biological profile throughout past decades.

Keywords:

Green chemistry, synthesis, biological activity, imidazole, anti-cancer, antibacterial.

Affiliation:

Synthetic Organic Chemistry Laboratory Department of Chemistry, MLSU, Udaipur 313001, Synthetic Organic Chemistry Laboratory Department of Chemistry, MLSU, Udaipur 313001, Synthetic Organic Chemistry Laboratory Department of Chemistry, MLSU, Udaipur 313001, Department of Pharmacy, B N University, Udaipur 313001, Synthetic Organic Chemistry Laboratory Department of Chemistry, MLSU, Udaipur 313001

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