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Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review

Author(s):

Aref Ghasemi Ghahsare, Zahra Sadat Nazifi* and Seyed Mohamad Reza Nazifi*   Pages 1 - 7 ( 7 )

Abstract:


Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds are consist of an oxygen-containing central heterocyclic structure with two more cyclic structure fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activity such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such compounds has been one of the main research in pharmaceutical chemistry. Due to this diverse biological activity, xanthene core derivatives are still an attractive research field for both academia and industry. This review addresses the current finding on biological activities of xanthene derivatives and discussed in detail some aspects of their structure-activity relationship (SAR).

Keywords:

Xanthene, structure-activity relationship (SAR), biological activity, polycyclic, natural resources, pharmaceutical activities

Affiliation:

Department of Chemistry, Shahreza Branch, Islamic Azad University, Shahreza, Isfahan, 86145-311, Department of Chemistry, Shahreza Branch, Islamic Azad University, Shahreza, Isfahan, 86145-311, Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, 81746-73461 Isfahan



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