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3,5-Bis(trifluoromethyl) Phenylammonium triflate(BFPAT) as a Novel Organocatalyst for the Efficient Synthesis of 2,3-dihydroquinazolin-4(1H)-one Derivatives

[ Vol. 17 , Issue. 1 ]

Author(s):

Mandana Alipour, Zinatossadat Hossaini, Samad Khaksar* and Faramarz Rostami-Charati   Pages 40 - 45 ( 6 )

Abstract:


Aims and Objectives: A one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives by threecomponent cyclo-condensation of isatoic anhydride, aldehydes and amine or ammonium acetate has been developed using 3,5-Bis(trifluoromethyl) phenylammonium triflate (BFPAT) as a new organocatalyst.

Materials and Methods: All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points.

Results: A wide variety of structurally different aldehydes reacted easily and rapidly to result in the relating 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yield.

Conclusion: We have demonstrated an extremely effective and new process for synthesizing 2,3- dihydroquinazolin-4(1H)-ones employing BFPAT as a novel organocatalyst in one-pot fashion.

Keywords:

Organocatalyst, green chemistry, quinazoline, multicomponent, heterocyclic, antitumor, anti-diabetes.

Affiliation:

Department of Chemistry, Islamic Azad University, Qaemshahr Branch, Qaemshahr, Department of Chemistry, Islamic Azad University, Qaemshahr Branch, Qaemshahr, Department of Chemistry, Islamic Azad University, Ayatollah Amoli Branch, Amol, Department of Chemistry, Faculty of Science, Gonbad Kavous University, P.O. Box 163, Gonbad Kavous

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