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Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents

[ Vol. 17 , Issue. 2 ]

Author(s):

Yan-Ling Tang, Yong-Kun Li, Min-Xin Li, Hui Gao*, Xiao-Bi Yang and Ze-Wei Mao*   Pages 136 - 143 ( 8 )

Abstract:


Background: Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections.

Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides.

Materials and Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated.

Results: The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.

Conclusion: Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.

Keywords:

Chalcone, sulphonamide, antibacterial activity, MIC, piperazine, Staphylococcus aureus.

Affiliation:

College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500

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