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Review of the Syntheses and Activities of Some Sulfur-Containing Drugs

[ Vol. 17 , Issue. 3 ]

Author(s):

Criscieli Taynara Barce Ferro, Beatriz Fuzinato dos Santos, Caren Daniele Galeano da Silva, George Brand, Beatriz Amaral Lopes da Silva and Nelson Luís de Campos Domingues*   Pages 192 - 210 ( 19 )

Abstract:


Background: Sulfur-containing compounds represent an important class of chemical compounds due to their wide range of biological and pharmaceutical properties. Moreover, sulfur-containing compounds may be applied in other fields, such as biological, organic, and materials chemistry. Several studies on the activities of sulfur compounds have already proven their anti-inflammatory properties and use to treat diseases, such as Alzheimer’s, Parkinson’s, and HIV. Moreover, examples of sulfur-containing compounds include dapsone, quetiapine, penicillin, probucol, and nelfinavir, which are important drugs with known activities.

Objective: This review will focus on the synthesis and application of some sulfur-containing compounds used to treat several diseases, as well as promising new drug candidates.

Conclusion: Due to the variety of compounds containing C-S bonds, we have reviewed the different synthetic routes used toward the synthesis of sulfur-containing drugs and other compounds.

Keywords:

Sulfur, C-S bond, RN-18, quetiapine, 3-arylthioindoles, ebsulfur, dapsone.

Affiliation:

Faculty of Exact Sciences and Technology, Organic Catalysis and Biocatalysis Laboratory – (LACOB), Federal University of Grande Dourados – UFGD, Dourados/MS, Faculty of Exact Sciences and Technology, Organic Catalysis and Biocatalysis Laboratory – (LACOB), Federal University of Grande Dourados – UFGD, Dourados/MS, Faculty of Exact Sciences and Technology, Organic Catalysis and Biocatalysis Laboratory – (LACOB), Federal University of Grande Dourados – UFGD, Dourados/MS, Faculty of Exact Sciences and Technology, Organic Catalysis and Biocatalysis Laboratory – (LACOB), Federal University of Grande Dourados – UFGD, Dourados/MS, Faculty of Exact Sciences and Technology, Organic Catalysis and Biocatalysis Laboratory – (LACOB), Federal University of Grande Dourados – UFGD, Dourados/MS, Faculty of Exact Sciences and Technology, Organic Catalysis and Biocatalysis Laboratory – (LACOB), Federal University of Grande Dourados – UFGD, Dourados/MS

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