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Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide

Author(s):

Marcel Lucas Almeida, Maria Cecilia Oliveria, Ivan da Rocha Pitta and Marina Galdino Pitta *   Pages 1 - 19 ( 19 )

Abstract:


Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory and analgesic, antitumor, antimicrobial, anticonvulsant, among others. The most well known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide, because this compound initially presented important sedative effects. This review approaches some of the recent and efficient chemical synthesis pathway to obtain phthalimide analogues. It is also presented a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.

Keywords:

phthalimide, thalidomide, medicinal chemistry, anti-tumor, anti-inflammatory, antimicrobial

Affiliation:

NUPIT-SG, Universidade Federal de Pernambuco , NUPIT-SG, Universidade Federal de Pernambuco , NUPIT-SG, Universidade Federal de Pernambuco , NUPIT-SG, Universidade Federal de Pernambuco



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