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Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide

[ Vol. 17 , Issue. 4 ]

Author(s):

Marcel L. Almeida, Maria C.V.A. Oliveira, Ivan R. Pitta and Marina G.R. Pitta *   Pages 252 - 270 ( 19 )

Abstract:


Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.

Keywords:

Phthalimide, thalidomide, medicinal chemistry, anti-tumor, anti-inflammatory, antimicrobial.

Affiliation:

Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Bioscience Center, Federal University of Pernambuco, Recife, Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Bioscience Center, Federal University of Pernambuco, Recife, Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Bioscience Center, Federal University of Pernambuco, Recife, Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Bioscience Center, Federal University of Pernambuco, Recife

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