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“An Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H-indazole by Grinding Method”

Author(s):

Santosh Raut*, Bharat Dhotre , Atul Tidke and Mohd. Arif Pathan   Pages 1 - 9 ( 9 )

Abstract:


Background: An eco-friendly, operationally simple and efficient reaction is shown between various 2,6-bis- (substituted-benzylidene)-cyclohexanone and different substituted hydrazine in presence of acetic acid.

Methods: The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanone and different substituted hydrazine in presence of acetic acid afford 7-Benzylidene-substituted-phenyl3,3a,4,5,6,7-hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using grindstone. technique.

Results: Mild synthetic conditions, weak acid catalysis, non-hazardous solvent and environmentally safe are notable advantages of this method.

Conclusion: In conclusion, we have developed an efficient, simple and eco-friendly method for synthesis of 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up, clean reaction profile.

Keywords:

Acetic acid, hydrazine; grindstone chemistry, 2H-indazoles; 2, 6-Bis- (substituted-benzylidene)-cyclohexanone.

Affiliation:

Maulana Azad College and Research Center Rouza Bagh Aurangabad (M.S.), Swami Vivekanand Sr. College Mantha Dist Jalna (M.S.), Maulana Azad College and Research Center Rouza Bagh Aurangabad (M.S.), Maulana Azad College and Research Center Rouza Bagh Aurangabad (M.S.)



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