Preetismita Borah*, V D Shivling, Bimal K Banik and Biswa Mohan Sahoo Pages 1 - 19 ( 19 )
In recent years, hybrid systems are drawing considerable attention owing to their various biological applications in the drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exists a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon-Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are the great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors to develop technologies are to less energy consumption and to avoid the use of hazardous reagents. In this case, microwave energy plays a vital alternative for chemical transformations since it takes care of two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and use of multicomponent reactions.
Microwave Energy, hybrid molecule, Carbon-Carbon bond formation, Ugi-4CR, Steroids.
CSIR-Central Scientific Instruments Organization, Chandigarh, CSIR-Central Scientific Instruments Organization, Chandigarh, Prince Mohammad Bin Fahd University, Al Khobar, Roland Institute of Pharmaceutical Sciences, Berhampur-760010, Odisha