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Highly Efficient Ultrasound Promoted Synthesis of 2-phenylquinoxaline in Glycerol- Water

Author(s):

Mujahed Shaikh*, Devendra Wagare, Ashvini Sonone and Ayesha Durrani   Pages 1 - 5 ( 5 )

Abstract:


Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.

Materials and Methods: Therefore, we have designed highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water.

Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratio give consistently higher yields (89–94%) and decrease reaction times.

Conclusion: The main advantages of this protocol are green method; avoid use of toxic catalyst and volatile organic medium and product obtained with excellent yield.

Keywords:

O-Phenylenediamine, Acetophenone, Trimethylsilyl Chloride, Glycerol, Ultrasound, Nbromosuccinimide.

Affiliation:

Department of chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (M.S.), Department of chemistry, Vivekanand College, Aurangabad , Department of chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (M.S.), Department of chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (M.S.)



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