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Highly Efficient Ultrasound Promoted Synthesis of 2-phenylquinoxaline in Glycerol- Water

[ Vol. 17 , Issue. 6 ]

Author(s):

Mujahed Shaikh*, Devendra Wagare, Ashvini Sonone and Ayesha Durrani   Pages 483 - 487 ( 5 )

Abstract:


Introduction: Quinoxalines show diversified applications in the field of medicinal chemistry.

Materials and Methods: Therefore, we have designed a highly efficient, environmentally benign and one-pot protocol for the synthesis of 2-phenylquinoxaline from the reaction of Acetophenone, N-bromosuccinimide and 1,2-phenylenediamine under ultrasound irradiation in glycerol-water.

Results and Discussion: We observed that, although the reaction efficiently completed in all of these solvents, the use of glycerol-water with different ratios gives consistently higher yields (89–94%) and decreases reaction times.

Conclusion: The main advantages of this protocol are that it is a green method, avoids the use of toxic catalysts and volatile organic medium and the product is obtained with excellent yield.

Keywords:

O-Phenylenediamine, Acetophenone, Trimethylsilyl Chloride, Glycerol, Ultrasound, N-bromosuccinimide.

Affiliation:

Department of Chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (M.S.), Department of Chemistry, Vivekanand College, Aurangabad, Department of Chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (M.S.), Department of Chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (M.S.)

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