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A Review on Thiocyanation of Indoles

[ Vol. 18 , Issue. 3 ]

Author(s):

Chitteti Divyavani, Pannala Padmaja, Vinod G. Ugale and Pedavenkatagari Narayana Reddy*   Pages 233 - 247 ( 15 )

Abstract:


Background: The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access 3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives.

Objective: The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on its scope and mechanism.

Conclusion: In this review, we have summarized various methods for the thiocyanation of indoles. Selection of new methods for the preparation of 3-thiocyanato-indoles will be done. The mechanistic aspects and significance of the methods are also briefly discussed.

Keywords:

Organosulfur compounds, thiocyanation, indoles, oxidants, acid catalysts, electrochemical thiocyanation, photocatalyzed thiocyanation.

Affiliation:

Department of Chemistry, Sri Padmavathi Women’s Degree & PG College, Tirupati, Andhra Pradesh, Fluoro & Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405, Maharashtra, Department of Chemistry, School of Science, Gitam Deemed to be University, Telangana

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