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A Review on Thiocyanation of Indoles

[ Vol. 18 , Issue. 3 ]


Chitteti Divyavani, Pannala Padmaja, Vinod G. Ugale and Pedavenkatagari Narayana Reddy*   Pages 233 - 247 ( 15 )


Background: The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access 3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives.

Objective: The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on its scope and mechanism.

Conclusion: In this review, we have summarized various methods for the thiocyanation of indoles. Selection of new methods for the preparation of 3-thiocyanato-indoles will be done. The mechanistic aspects and significance of the methods are also briefly discussed.


Organosulfur compounds, thiocyanation, indoles, oxidants, acid catalysts, electrochemical thiocyanation, photocatalyzed thiocyanation.


Department of Chemistry, Sri Padmavathi Women’s Degree & PG College, Tirupati, Andhra Pradesh, Fluoro & Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur- 425405, Maharashtra, Department of Chemistry, School of Science, Gitam Deemed to be University, Telangana

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